Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following L… (NCT07740382) | Clinical Trial Compass
RecruitingNot Applicable
Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection
Egypt116 participantsStarted 2026-07-01
Plain-language summary
This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.
The investigators hypothesize that bilateral ESP block improves postoperative respiratory function compared with EOIP block following open hepatic surgery. The investigators further hypothesize that this improvement is mediated, in part, by superior analgesia.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients aged 18-75 years
* Adult with American Society of Anesthesiologists (ASA) physical status I-III
* Scheduled for elective hepatic surgery via upper abdominal incisions will be eligible.
* All participants will be required to understand the Numeric Rating Scale (NRS) and provide informed consent.
Exclusion Criteria:
* Patient refusal
* Coagulopathy (INR\>1.4 or platelet count\<8 x 104)
* Contraindications to fascial plane blocks
* Infection at the puncture site
* Known allergy to study medications
* Chronic opioid use or chronic pain syndromes
* Severe chronic respiratory failure requiring home oxygen or noninvasive ventilation
* Pregnancy
* Body mass index\>40 kg/m²
* When ultrasound imaging will be deemed unreliable
* Emergency surgery
* Hemodynamic instability
* Reoperation during the same hospital admission.
* Patients scheduled preoperatively for elective postoperative mechanical ventilation or planned ICU intubation.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Right diaphragmatic excursion
Timeframe: Baseline, and 1, 6, and 24 hours after surgery.