NAD Supplementation to Reduce the Incidence of Cardiac Surgery Associated Acute Kidney Injury (NCT07739290) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
NAD Supplementation to Reduce the Incidence of Cardiac Surgery Associated Acute Kidney Injury
20 participantsStarted 2026-09-01
Plain-language summary
The purpose of this single-center, randomized, double-blinded placebo-controlled pilot trial is to demonstrate feasibility and help design a larger trial to assess the effectiveness of nicotinamide (NAM) supplementation in reducing risk of post-operative AKI in patients undergoing cardiac surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥18 years
. Undergoing coronary artery bypass graft (CABG) and/or valve surgery with cardiopulmonary bypass (CPB) at BIDMC. Includes combination surgeries that involve CABG and/or valve plus other procedures (e.g., Maze procedure, aortic aneurysm repair).
. AKI risk score ≥6 at the time of screening
Exclusion criteria
. History of AKI in the seven days prior to surgery, defined as any of the following:
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at NAD supplementation to try to prevent acute kidney injury after cardiac surgery — is my upcoming surgery the kind that would put me at risk for this complication, and is that something my care team is already monitoring for?
2The trial is measuring a specific kidney injury marker called KIM-1 in urine on the first day after surgery — can you explain what that tells us about kidney health, and whether my baseline kidney function would be relevant to whether this kind of study might apply to my situation?
3Since this trial isn't recruiting yet, is there any standard approach my surgical team already uses to protect my kidneys during and after cardiac surgery that I should know about before considering whether a study like this would even add anything?
4NAD supplementation is described as a nutritional or metabolic approach rather than a traditional drug — what does my care team know about its safety profile in the context of cardiac surgery, especially since this trial is listed as Phase NA, meaning it may be early or exploratory?
5If this trial opens up and my doctor thinks it could be relevant to me, what would participation actually look like in terms of extra procedures, visits, or tests beyond my normal surgical recovery?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post Operative day 1 urinary KIM-1
Timeframe: From enrollment to 1 day post cardiac surgery