Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction (NCT07738861) | Clinical Trial Compass
CompletedPhase 4
Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction
Pakistan74 participantsStarted 2026-01-10
Plain-language summary
Postoperative pain is a common complication following mandibular molar extraction and can negatively affect patient comfort and recovery. Tetracycline is a broad-spectrum antibiotic with anti-inflammatory properties that may reduce postoperative inflammation and pain when applied locally to the extraction socket.
This randomized controlled trial aims to evaluate the effect of intraoperative placement of tetracycline on postoperative pain in patients undergoing surgical extraction of mandibular molars. A total of 74 eligible patients will be randomly assigned to receive either intrasocket tetracycline or no local medicament following tooth extraction. All participants will receive the same standard postoperative care and analgesic regimen. Postoperative pain will be assessed using the Visual Analog Scale (VAS) at 24 hours, 48 hours, and 7 days after surgery. The findings of this study will provide evidence regarding the effectiveness of local tetracycline in reducing postoperative pain and may help improve postoperative pain management following mandibular molar extraction.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Adults aged 18 to 60 years. Male and female participants. Patients requiring surgical extraction of a mandibular molar. American Society of Anesthesiologists (ASA) Physical Status I or II. Able and willing to provide written informed consent and comply with study follow-up.
Exclusion Criteria:
Pregnant or lactating women. Patients with systemic conditions that contraindicate oral surgery (e.g., uncontrolled diabetes mellitus or immunosuppressive disorders).
Current use of antibiotics or medications that may interfere with wound healing (e.g., anticoagulants or bisphosphonates).
Known allergy or hypersensitivity to tetracycline or related antibiotics. Requirement for simultaneous extraction of adjacent teeth. Presence of active oral infection, including pericoronitis, at the surgical site.
Severely compromised oral hygiene that may affect postoperative healing. Individuals who are unable to cooperate with the study procedures or attend follow-up visits because of physical or cognitive impairment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative Pain Intensity
Timeframe: 24 hours, 48 hours, and 7 days after mandibular molar extraction
Trial details
NCT IDNCT07738861
SponsorCMH Lahore Medical College and Institute of Dentistry