Terbinafine for CSA-AKI Prevention

Inclusion Criteria: * Aged ≥18 and ≤75 years, without restriction on gender. * Patients with a definite clinical diagnosis scheduled for elective cardiac and macrovascular surgery with cardiopulmonary bypass (CPB) support, including but not limited to coronary artery bypass grafting (CABG), cardiac valve replacement/repair, structural heart disease surgery, aortic arch plasty, or combined procedures of the above surgeries. * Classified as high risk by AKI risk scoring system, with a total score ≥4 points. * The subject or their legal representative shall fully understand the purpose, procedures, potential risks and benefits of this study, and voluntarily sign the written informed consent form. Exclusion Criteria: * Patients with severe chronic renal insufficiency (eGFR \< 50 mL/min/1.73 m² or serum creatinine \> 300 μmol/L), or those receiving any form of renal replacement therapy (e.g., hemodialysis, peritoneal dialysis). * Pre-existing acute kidney injury. * Presence of chronic or active liver diseases, including decompensated liver cirrhosis, active viral hepatitis, autoimmune liver disease, etc.; or preoperative laboratory tests showing ALT/AST ≥ 2 times the upper limit of normal (ULN). * Severe hematological diseases (preoperative white blood cell count \< 3.0 × 10⁹/L, platelet count \< 80 × 10⁹/L). * Uncontrolled active infections, or known immunodeficiency disorders (e.g., HIV infection, status post organ transplantation). * History of severe hypersensitivity to ter…