Efficacy of Liquid Phase Concentrated Growth Factors as an Adjunct to EDTA in the Treatment of Re… (NCT07736833) | Clinical Trial Compass
CompletedNot Applicable
Efficacy of Liquid Phase Concentrated Growth Factors as an Adjunct to EDTA in the Treatment of Recession Type 1 Defect With Free Gingival Graft
Egypt20 participantsStarted 2024-02-21
Plain-language summary
The present study was designed to investigate the clinical efficacy of liquid-phase concentrated growth factors (LPCGF) as an adjunct to ethylenediaminetetraacetic acid (EDTA) for root surface biomodification prior to free gingival grafting for the management of Cairo type 1 gingival recession defects.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 to 50 years old.
* Patients with good systemic health with no contraindication for periodontal surgery.
* No history of systemic or local medications within the previous six months that could affect periodontal tissue health or wound healing.
* Recession depth ≥ 3 mm, measured from the cementoenamel junction (CEJ) to the gingival margin and/ or width of attached gingiva \< 3 mm.
* Presence of identifiable cementoenamel junction (CEJ).
* Absence of interproximal attachment loss (i.e., intact interdental bone and soft tissue, confirmed radiographically).
* Ability to maintain adequate oral hygiene, as demonstrated during recall visits.
Exclusion Criteria:
* Restoration or caries in the site to be treated or non-vital tooth.
* Previous mucogingival surgery at the defect.
* Active infectious diseases (hepatitis, HIV, etc.).
* Smokers and pregnant patients.
* Teeth that are tilted rotated or have any non-alterable occlusal abnormalities.
* Sites with tooth mobility.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Width of attached gingiva (AG)
Timeframe: Baseline, 1 month, 3 months, and 6 months
2
Gingival thickness (GT)
Timeframe: baseline, 1 month, 3 months, and 6 months