A Blood Pressure-Lowering Diet for Preventing and Managing Hypertension (NCT07735091) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
A Blood Pressure-Lowering Diet for Preventing and Managing Hypertension
China800 participantsStarted 2026-08-01
Plain-language summary
This cluster-randomized controlled trial will evaluate whether a 3-month culturally adapted blood pressure-lowering dietary, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure and related health outcomes in Chinese adults with primary hypertension.
Approximately 800 participants from 16 workplace-based clusters will be assigned to either a standard hypertension management group or a dietary intervention group. Both groups will receive usual hypertension care, including health education and medication treatment when clinically indicated. In addition, participants in the dietary intervention group will receive specially designed weekday lunches, low-sodium salt and reduced-sodium seasonings, and app-based support for dietary recording and adherence monitoring.
The main outcome is change in resting systolic and diastolic blood pressure. Other outcomes include body weight, waist circumference, body fat, blood glucose, blood lipids, homocysteine, kidney function, estimated 24-hour urinary sodium and potassium excretion, lifestyle behaviors, sleep, psychological well-being, and the occurrence of hypertension-related complications or cardiovascular and cerebrovascular events. Blood, urine, and stool samples will also be analyzed to explore possible metabolic and gut microbiome mechanisms underlying the effects of the dietary intervention.
The active dietary intervention will last 3 months, and participants will be followed for up to 24 months.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 18 to 60 years.
* Employed by Shengli Oilfield and regularly receiving meals from a participating workplace canteen.
* Regularly eats at the participating canteen, generally on at least 4 working days per week.
* Diagnosed with primary hypertension by a qualified medical institution, or meets the diagnostic criterion of systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg on 3 measurements obtained on different days.
* Hypertension is clinically stable.
* Antihypertensive medication regimen is stable, when applicable.
* Able and willing to comply with the dietary intervention, study assessments, and follow-up procedures.
* Provides written informed consent voluntarily.
Exclusion Criteria:
* Secondary hypertension.
* Pregnancy, breastfeeding, or planning to become pregnant during the study period.
* Serious food allergy or intolerance to major foods included in the intervention diet, such as nuts, dairy products, or gluten-containing foods.
* Major cardiovascular or cerebrovascular event within the previous 6 months, such as myocardial infarction or stroke.
* Severe cardiopulmonary disease, such as heart failure or severe asthma.
* Cancer, advanced kidney disease, severe liver disease, or another serious medical condition.
* A medical condition requiring a specialized therapeutic diet that would interfere with the study intervention.
* Severe psychiatric illness.
* Severe cognitive impairment that prevents understanding of th…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Resting Systolic Blood Pressure
Timeframe: Baseline and 3 month after baseline survey
2
Resting Diastolic Blood Pressure
Timeframe: Baseline and 3 months after baseline survey