CompletedNot Applicable

Effect of Trypan Blue on Corneal Endothelial Cell Count During Phacoemulsification

Pakistan60 participantsStarted 2024-03-22

Plain-language summary

This randomized controlled trial evaluated the effect of trypan blue on corneal endothelial cell count in patients undergoing phacoemulsification for age-related cataract. Sixty participants were randomly assigned to undergo phacoemulsification either with trypan blue-assisted anterior capsule staining or without trypan blue. The primary objective was to compare postoperative corneal endothelial cell count between the two groups using specular microscopy to determine whether trypan blue has an effect on corneal endothelial cell loss during cataract surgery.

Who can participate

Age range

18 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 45 to 75 years. * Diagnosed with age-related cataract. * Scheduled to undergo phacoemulsification with posterior chamber intraocular lens implantation. * Able and willing to provide written informed consent. Exclusion Criteria: * Diabetes mellitus. * Glaucoma. * Previous ocular surgery. * Corneal opacity. * Pre-existing corneal endothelial disease. * Uveitis. * Traumatic cataract. * Complicated cataract. * Any other ocular pathology that could affect corneal endothelial cell count or interfere with study outcomes.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Postoperative Corneal Endothelial Cell Count

Timeframe: At 4 weeks after surgery

Postoperative Corneal Endothelial Cell Count

Timeframe: At 4 weeks after surgery

Trial details

NCT IDNCT07735000

SponsorHayat Abad Medical Complex, Peshawar

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2024-09-22

View on ClinicalTrials.gov More Age Related Cataract trials