A Prompt REstart Study of Renin-Angiotensin System Inhibitors After Acute Kidney Injury (NCT07734636) | Clinical Trial Compass
Not Yet RecruitingPhase 4
A Prompt REstart Study of Renin-Angiotensin System Inhibitors After Acute Kidney Injury
United States60 participantsStarted 2026-08
Plain-language summary
The goal of this pilot clinical trial is to learn if early restart of renin-angiotensin system inhibitor (RASi) medications is feasible and well-tolerated in hospitalized patients with acute kidney injury (AKI). Researchers will compare early RASi restart to usual care.
Study participants will restart RASi per study protocol, obtain a lab test in 1-2 weeks if RASi restarted in the hospital and not collected as part of routine care, and answer questions at the 90-day follow-up.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* Pre-admission RASi use for Class I indication (e.g., heart failure, kidney disease)
* RASi stopped in the setting of AKI (defined by ≥1.5x baseline SCr)
* AKI in recovery (defined by a decrease in SCr by ≥0.3mg/dL from peak)
Exclusion Criteria:
* RASi allergy or contraindication (i.e., angioedema, bilateral renal artery stenosis)
* Ongoing dialysis requirement
* Pregnant or breastfeeding
* Prisoner
* Palliative or hospice care involvement
* Unable to consent
* No enteral route of medication administration
* Clinician judgment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically about restarting blood pressure medications called RAS inhibitors after an acute kidney injury — if I've been on one of those medications and then had a kidney injury, is this study something worth discussing with my care team?
2Since this is a Phase 4 trial, that means the medications involved are already approved, but is the main goal here to figure out whether it's even feasible to safely restart these drugs after a kidney injury, rather than to prove they work — and what does that mean for what's actually known about the risks of restarting them?
3The trial isn't recruiting yet, so how long do you think it might be before it opens, and would waiting for it potentially delay other important treatment decisions for my kidney health?
4The primary outcome is measuring something called 'RAS inhibitor use separation,' which sounds like it's tracking whether people in the study actually end up on different treatment paths — can you explain what that means for me practically, and whether being in this trial might change which medications I'd be prescribed?
5Given that this study is still in an early feasibility stage, would you recommend I consider restarting my RAS inhibitor now based on current evidence, or is the uncertainty around timing after kidney injury exactly the kind of question this trial is designed to answer?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility- RASi use separation
Timeframe: From date of enrollment until date of hospital discharge or up to 90 days if remains in the hospital