Not Yet RecruitingNot Applicable

Vitamin D Status and Asthma Control, Pulmonary Function, and Oxidative Stress in Adults With Bronchial Asthma

134 participantsStarted 2026-07-26

Plain-language summary

Asthma is a chronic inflammatory airway disease associated with variable airflow limitation and persistent respiratory symptoms. Vitamin D has been proposed as a potential biomarker related to immune regulation, asthma control, pulmonary function, and oxidative stress balance. This prospective cross-sectional observational study aims to investigate the association between serum 25-hydroxyvitamin D \[25(OH)D\] concentrations, asthma control, pulmonary function parameters, and erythrocyte oxidative stress biomarkers among Egyptian adults with bronchial asthma. A total of 200 adult asthma patients will be recruited from Abbassia Chest Hospital, Cairo, Egypt. Participants will undergo clinical assessment, Asthma Control Test (ACT), post-bronchodilator spirometry, serum vitamin D measurement, and oxidative stress biomarker assessment including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione (GSH). Participants will be categorized according to serum 25(OH)D concentrations into vitamin D deficient, insufficient, and sufficient groups. No intervention or treatment assignment will be performed. 5\. Detailed Description

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Age ≥ 18 years. * Confirmed diagnosis of bronchial asthma. * Clinically stable at the time of assessment. * Availability of spirometry results. * Availability of laboratory investigations including serum 25(OH)D and oxidative stress biomarkers. Exclusion Criteria * Other chronic pulmonary diseases. * Active respiratory infection. * Malignancy. * Significant renal or hepatic disease. * Pregnancy. * Current vitamin D supplementation. * Other conditions known to markedly influence oxidative stress status.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is looking at the relationship between vitamin D levels and asthma control — do you think my current vitamin D status could be affecting how well my asthma is managed, and is that worth testing before I consider joining a study like this?
2The trial isn't recruiting yet, so if I'm interested, how long might I realistically have to wait, and should I be pursuing other treatment adjustments in the meantime rather than waiting?
3Since this study is measuring asthma control using the Asthma Control Test score, can you walk me through what my current ACT score is and whether my asthma is considered controlled or uncontrolled right now?
4This trial also looks at oxidative stress and pulmonary function — are there already established treatments or lifestyle changes that address these factors in asthma that I should know about before considering a research study?
5Because this is listed as Phase NA, which often means it's more of an observational or measurement study rather than a treatment trial, can you help me understand whether participating would actually change my treatment, or would it mainly be contributing data to research?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Asthma Control Level Measured by Asthma Control Test (ACT) Score

Timeframe: Single baseline assessment.

Trial details

NCT IDNCT07733635

SponsorSinai University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-30

View on ClinicalTrials.gov More Bronchial Asthma trials