Not Yet RecruitingNot Applicable

Listen Aphasia Pilot Study

United States80 participantsStarted 2027-01

Plain-language summary

This is a feasibility and pilot study to refine and test LISTEN, an AI-based augmentative and alternative communication (AAC) smartphone app, integrated into the patient's personal electronic device, to augment and facilitate communication in patients with tumor-related aphasia (TRA) and their care partners. The study will assess the feasibility and acceptability of LISTEN in patients with TRA and their care partners.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

Unable to read or respond to questions in English

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Usability of LISTEN Assessed by the System Usability Scale (SUS) [Phase 1]

Timeframe: Up to 12 months (Phase 1 refinement period).

Acceptability of LISTEN Assessed by Acceptability of Intervention Measure (AIM) [Phase 2]

Timeframe: Up to 24 months (pre-pilot study period).

Appropriateness of LISTEN Assessed by Intervention Appropriateness Measure (IAM) [Phase 2]

Timeframe: Up to 24 months (pre-pilot study period).

Feasibility of LISTEN Assessed by Feasibility of Intervention Measure (FIM) [Phase 2]

Timeframe: Up to 24 months (pre-pilot study period).

Acceptability of LISTEN Assessed by Acceptability of Intervention Measure (AIM) [Phase 3]

Timeframe: At the end of the open pilot study (up to 48 months).

Appropriateness of LISTEN Assessed by Intervention Appropriateness Measure (IAM) [Phase 3]

Timeframe: At the end of the open pilot study (up to 48 months).

Trial details

NCT IDNCT07732140

SponsorDana-Farber Cancer Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-05

Contact for this trial

John Rhee, MD, MPH

(857) 215-3308 John_Rhee@DFCI.HARVARD.EDU

View on ClinicalTrials.gov More Aphasia trials

Plain-language summary

What they're measuring

Usability of LISTEN Assessed by the System Usability Scale (SUS) [Phase 1]

Timeframe: Up to 12 months (Phase 1 refinement period).

Acceptability of LISTEN Assessed by Acceptability of Intervention Measure (AIM) [Phase 2]

Timeframe: Up to 24 months (pre-pilot study period).

Appropriateness of LISTEN Assessed by Intervention Appropriateness Measure (IAM) [Phase 2]

Timeframe: Up to 24 months (pre-pilot study period).

Feasibility of LISTEN Assessed by Feasibility of Intervention Measure (FIM) [Phase 2]

Timeframe: Up to 24 months (pre-pilot study period).

Acceptability of LISTEN Assessed by Acceptability of Intervention Measure (AIM) [Phase 3]

Timeframe: At the end of the open pilot study (up to 48 months).

Appropriateness of LISTEN Assessed by Intervention Appropriateness Measure (IAM) [Phase 3]

Timeframe: At the end of the open pilot study (up to 48 months).