Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition (NCT07731529) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition
Brazil54 participantsStarted 2026-07
Plain-language summary
This randomized clinical trial investigates the effects of a home-based multicomponent exercise program (Vivifrail) on physical function, muscle morphology, and cognition in community-dwelling adults aged 90 years and older. Participants are randomized into three groups: Vivifrail at least twice a week, Vivifrail at least three times a week, or a control group. Outcomes are assessed at baseline, 12 weeks, and 24 weeks. The primary outcome is physical function measured by the Short Physical Performance Battery (SPPB).
Who can participate
Age range
90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 90 years or older
* Living in the community (own or family home)
* Able to walk independently or with a walking aid (cane or walker), without third-party assistance
* Minimum cognitive capacity to understand and perform the exercises (MMSE, education-adjusted cutoffs)
* Adequate home conditions to perform the program
* Availability of a family member or caregiver to support the sessions
* Signed informed consent (with legal guardian assistance when needed)
Exclusion Criteria:
* \- Total inability to walk or permanent bedridden condition
* Severe cognitive impairment preventing safe understanding and execution of exercises
* Severe orthopedic, neurological, or rheumatological conditions preventing exercise
* Concurrent participation in another structured exercise program
* Anticipated unavailability (relocation, planned hospitalization, or institutionalization) during the intervention
* Refusal to sign informed consent or absence of a legal guardian when required
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in physical function measured by the Short Physical Performance Battery (SPPB) total score
Timeframe: Baseline (T0), 12 weeks (T1), and 24 weeks (T2)