Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery (NCT07730294) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery
United States75 participantsStarted 2026-08
Plain-language summary
This study is testing whether oxytocin can help lessen pain by changing how people process emotions and social experiences. The goal is to better understand how the brain links emotions, relationships, and pain, and whether this connection can be used to improve pain treatment.
Who can participate
Age range
30 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: Between 30 to 75 years old.
* Consent: Ability to give informed consent.
* Language: Proficiency in the English language.
* Medical Condition: Diagnosed with a pituitary lesion requiring surgery.
* Menopausal Status: Post-menopause for women (at least 1 year since last menstrual period).
Exclusion Criteria:
* Medication: Individuals on stable doses of psychotropic medication for at least the past six weeks are eligible, excluding those with changes in medication within that timeframe.
* Neurological Conditions: A history of seizures, current use of anticonvulsants.
* Pregnancy: Currently pregnant, currently lactating, or up to 1-year post partum.
* Any history of renal impairment (serum creatinine \>1.2 x ULN)
* Any history of hepatic impairment (AST and/or ALT \>2 x ULN)
* Surgical History: Any history of previous pituitary surgery procedures
* Subjects who require 24-hour coverage with NSAIDs, e.g., arthritis, should not be included in the study.
* Any known hypersensitivity to TNX-1900
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in post-operative pain measured by the Numeric Pain Rating Scale (NPRS)
Timeframe: Pre-op up to 8 weeks after last drug administration
2
Change in post-operative pain measured by monitoring of pain medication usage
Timeframe: Pre-op up to 8 weeks after last drug administration