Exercise and Taurine Supplementation on Intramuscular Fat in Older Women With Obesity (NCT07730255) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Exercise and Taurine Supplementation on Intramuscular Fat in Older Women With Obesity
Brazil44 participantsStarted 2026-05-01
Plain-language summary
This randomized clinical trial aims to investigate the effects of multicomponent concurrent exercise training associated or not with taurine supplementation on intramuscular fat infiltration, physical performance, transcriptomic profile, and metabolomic profile in older women with obesity. Forty women aged 60 to 75 years with obesity will be randomized into four groups: control, exercise, taurine, and exercise plus taurine. The intervention will last 16 weeks. Outcomes include magnetic resonance imaging, body composition, muscle biopsy, blood biomarkers, functional capacity tests, transcriptomic analysis, and metabolomic analysis.
Who can participate
Age range
60 Years – 75 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female,
* 60 and 75 years of age,
* Body mass lower than 120 kg,
* Be sedentary (not having engaged in physical exercise for at least 3 months), and
* Body Mass Index between 30 and 40 kg/m².
Exclusion Criteria:
* alcohol consumption,
* smoking,
* infectious and contagious diseases,
* chronic kidney diseases,
* undergoing weight loss treatment, and
* presenting a score ≤13 on cognitive screening using the Mini-Mental State Examination (MMSE).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline in Intramuscular Fat Fraction Assessed by Magnetic Resonance Imaging (Dixon Technique)
Timeframe: Baseline and 16 weeks
2
Change from baseline in skeletal muscle transcriptomic profile
Timeframe: Baseline and 16 weeks
3
Change from baseline in plasma metabolomic profile
Timeframe: 16 weeks
4
Change from baseline in plasma taurine concentration