An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the Face

Inclusion Criteria: * Provided written Informed Consent. * Patient is willing and able to comply with study protocol, visit schedule, and other study-related instructions/procedures, including in-clinic stay as required. * Patient is a male or non-pregnant female 18 to 85 years of age (inclusive) at Screening. * Patient has either 4 or more AK lesions on the upper extremities; or 6 or more AK lesions on the face. Lesions must be within an area of 25 cm2. * Patient is in good general health and free of any disease state or physical condition. * Patient has veins suitable for repeat blood draws. * Patient is willing to abstain from sunbathing, solarium use, exposure to artificial tanning devices. * Patient is willing to follow a consistent skin care routine without significant change. * Patient is willing to stop using all topical products within the Treatment Area(s) starting from 8 hours prior to initiation of treatment. * Patients who are women of childbearing potential must agree to use a highly effective method of contraception during the study. * Patients who are male with female partners of childbearing potential must use a barrier method of contraception (e.g., condom) if not surgically sterile. * Females of childbearing potential must have a negative serum pregnancy test at Screening and a negative urine pregnancy test before initiation of treatment at Baseline. Exclusion Criteria: * Patient is pregnant, lactating, or is planning to become pregnant during the study.…