Not Yet RecruitingNot Applicable

Advancing Precision Medicine for Cardiovascular Disease and Diabetes in Asian Populations: Digital Intervention Cohort

Singapore600 participantsStarted 2026-07-20

Plain-language summary

The overarching aim is to improve cardiometabolic health and promote healthy ageing by supporting adults to adopt favourable lifestyle patterns identified through our observational research. The trial will recruit n=600 to be involved in Phase I (referred to as the "Optimisation Phase") of a two-phase project (Phase II trial registration will be submitted separately). All participants will complete a baseline study visit where, after consent taking, will complete a baseline questionnaire, receive a smartwatch each and additional wearables if applicable, and download the study app for the receiving and testing of interventions and completion of short form surveys. Participants will be involved in the continual evaluation and optimisation of ecological momentary interventions (EMIs) in adaptive, factorial, micro-randomised trials over 12 months. Consenting participants may also be contacted to participate in interviews to be involved in the co-design of interventions, or to provide insights to the feasibility and process evaluation of the trial.

Who can participate

Age range

21 Years – 69 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * are currently enrolled in the Singapore Population Health Studies - Multi-Ethnic Cohort Phase 3 (MEC3) or Second Follow-up (F2), * are of Chinese, Malay, or Indian ethnicity, * are 21 to 69 years old, and * can read and write English, * own or use a smartphone (iOS ≥ 12.4 or Android ≥ 8 with at least 5 GB of free storage, and data plan and internet access), * are able and willing to download and use study smartphone apps, * are able and willing to wear the smartwatch provided throughout the study period, and * can walk independently. Exclusion Criteria: * have a history or current condition of stroke, heart attack, kidney failure, diabetes mellitus, thyroid disease, or cancer, or have had a vascular bypass surgery or angioplasty procedure (either stent or balloon) performed, or * a serious mental health condition including schizophrenia, psychotic depression, or severe dementia, or * are currently pregnant or planning to get pregnant during the study period, or * are participating or planning to participate in other lifestyle intervention studies. * have a known sensitivity to medical-grade adhesives or a bleeding disorder will be \[applicable to continuous glucose monitoring component only\] * with contraindications specified by the blood pressure monitoring device manufacturer \[applicable to continuous blood pressure monitoring component only\] * participated in the pilot study \[applicable to main trial only\].

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Number of participants having sufficient physical activity

Timeframe: At baseline, and every 5 weeks, up to 52 weeks from joining the study

Number of participants having sufficient sleep

Timeframe: At baseline, and every 5 weeks, up to 52 weeks from joining the study

Number of participants meeting dietary guidelines

Timeframe: At baseline, and every 5 weeks, up to 52 weeks from joining the study

Trial details

NCT IDNCT07728799

SponsorNational University of Singapore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2031-06-30

Contact for this trial

Sarah Yi Xuan Tan, PhD

+65 65164988 sarah.tan@nus.edu.sg

View on ClinicalTrials.gov More Physical Activity trials

Plain-language summary

Who can participate

Age range

21 Years – 69 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Number of participants having sufficient physical activity

Timeframe: At baseline, and every 5 weeks, up to 52 weeks from joining the study

Number of participants having sufficient sleep

Timeframe: At baseline, and every 5 weeks, up to 52 weeks from joining the study

Number of participants meeting dietary guidelines

Timeframe: At baseline, and every 5 weeks, up to 52 weeks from joining the study