Effects of Ozone Therapy on Muscle Damage (NCT07728422) | Clinical Trial Compass
CompletedNot Applicable
Effects of Ozone Therapy on Muscle Damage
Turkey (Türkiye)32 participantsStarted 2024-10-04
Plain-language summary
The goal of this clinical trial is to determine the effectiveness of different ozone therapy methods in enhancing recovery after muscle-damaging exercise in healthy adults, and to evaluate their impact on biochemical markers of muscle damage and fatigue.
The main questions it aims to answer are:
* Do ozone-based interventions accelerate recovery by reducing biochemical markers of muscle damage and fatigue following eccentric exercise?
* Which ozone therapy modality provides the greatest recovery benefit? Researchers will compare three intervention groups (autohemotherapy, ozone sauna therapy, and ozonated lavender oil massage) with a control group receiving no treatment.
Participants will:
* Complete a standardized eccentric exercise protocol designed to induce muscle damage
* Receive one of the assigned interventions or no treatment (control)
* Provide blood samples at multiple time points (baseline, post-exercise, post-intervention, and 24, 48, and 72 hours follow-up) to assess recovery- related biomarkers
Who can participate
Age range
18 Years – 30 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* male football players aged 18-30 years
* playing exclusively in the midfield position
* active participation in regional professional football leagues (non-top-tier)
* engagement in regular football training at least four sessions per week with a minimum duration of 90 minutes per session
* absence of acute or chronic musculoskeletal injuries within the preceding six months
* no use of anti-inflammatory medications or ergogenic supplements within the four weeks prior to the study
Exclusion Criteria:
* female football players
* diagnosed cardiovascular, metabolic, or neurological disorders
* known hypersensitivity to ozone exposure or lavender oil
* any surgical intervention within the past six months
* concurrent participation in alternative recovery or therapeutic interventions during the study period
* playing positions other than midfield
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
CK
Timeframe: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.