EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders (NCT07727356) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders
Switzerland100 participantsStarted 2026-07-03
Plain-language summary
The goal of this trial is to learn whether wearable devices and hormone sampling can measure how the body changes during daily-life challenges in adults with endocrine or metabolic disorders. These disorders include conditions such as high blood pressure, adrenal disorders, diabetes, obesity, thyroid disorders, pituitary disorders, and other hormone-related conditions.
The main questions it aims to answer are:
Can wearable devices measure changes in blood pressure, heart rate, sleep, activity, temperature, and glucose during changes in salt intake, meals, fasting, and short exercise? Do these changes differ between people with different endocrine or metabolic disorders? Are wearable devices acceptable and practical for participants to use at home?
There is no comparison group in this study. Each participant will serve as their own comparison by completing different study phases.
Participants will wear study devices at home to measure blood pressure, heart rate, activity, sleep, temperature, and glucose, follow a low-salt diet for about 1 week and then a high-salt diet for about 1 week, using study instructions, complete meal, fasting, and short exercise tasks, give urine and saliva samples, and possibly blood samples, during the study. Optionally wear a hormone sampling device for about 27 hours, complete short questionnaires about symptoms, sleep, physical activity, and their experience using the devices.
The study will help researchers understand whether wearable monitoring can support future diagnosis and care for people with endocrine and metabolic disorders.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Diagnosis or suspected diagnosis of at least one endocrine or metabolic disorder, including:
* Overweight or obesity, defined as body mass index of 25 kg/m² or higher
* Essential hypertension
* Diabetes mellitus, including type 1 diabetes, type 2 diabetes, gestational diabetes, maturity-onset diabetes of the young, or unclassified diabetes
* Hypoglycemia
* Endogenous hypercortisolism
* Primary aldosteronism
* Endogenous or exogenous adrenal insufficiency
* Congenital adrenal hyperplasia
* Polycystic ovary syndrome
* Adrenocortical tumor or adrenal incidentaloma
* Functional or non-functional pituitary tumor
* Pituitary insufficiency
* Polyuria-polydipsia syndrome
* Hyponatremia
* Functional or non-functional neuroendocrine tumor
* Osteoporosis
* Lipid disorder
* Thyroid disorder
* Hypoparathyroidism or hyperparathyroidism
* Inborn error of metabolism
* People undergoing gender-affirming hormone therapy
Exclusion Criteria:
* Known or suspected severe skin disorder or allergy that may interfere with wearable sensor placement, such as extensive eczema, psoriasis, chronic ulcers, or severe tape intolerance
* Known impaired wound healing or strong keloid tendency that would make repeated skin application or microneedle use unsuitable
* Pregnancy or lactation, for participation in home monitoring or dynamic hormone sampling
* Known or suspected bleeding disorder, such as von Willebrand disease
* Current treatment with anticoagulant or antiplatelet therapy at…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in 24-hour systolic blood pressure
Timeframe: From Day 6 (end of low-sodium phase) to Day 13 (end of high-sodium phase)