Cardiovascular Autonomic Function After Resistance Training (NCT07725952) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Cardiovascular Autonomic Function After Resistance Training
South Korea20 participantsStarted 2026-07-27
Plain-language summary
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and quality of life.
Participants will be randomly assigned to either the resistance training group or the control group. All participants will complete assessments before and after the 8-week study period, including measurements of HRV, BRS, blood pressure responses during a tilt-table test, hand grip strength, and questionnaires assessing orthostatic hypotension symptoms and quality of life. Participants assigned to the resistance training group will participate in supervised upper-limb resistance training three times per week for 8 weeks.
Who can participate
Age range
19 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Provided written informed consent and agreed to participate in the study.
* Adults aged 19 to 85 years.
* Chronic spinal cord injury (SCI) of traumatic or non-traumatic etiology, at least 6 months after injury.
* Cervical or thoracic spinal cord injury.
* Classified as American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, C, or D.
* Sufficient upper-limb range of motion to perform resistance training.
* Elbow extensor muscle strength of Manual Muscle Test (MMT) grade 3 or higher.
Exclusion Criteria:
* Presence of any serious medical condition that would preclude participation in the study.
* Inability to understand or perform the exercise program.
* Uncontrolled diabetes mellitus or progressive neurological disease.
* Uncontrolled hypertension (systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg).
* History of cardiovascular disease within the past 6 months.
* Current use of medications that may affect heart rate variability (HRV) or baroreflex sensitivity (BRS).
* Severe orthostatic hypotension (OH) or autonomic dysreflexia (AD).
* Considered unsuitable for participation in the study by a board-certified specialist in Physical and Rehabilitation Medicine.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.