Ten Years Follow-up After the Arthroscopic Repair of Osteochondral Lesions of the Talus Via Autol… (NCT07725770) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Ten Years Follow-up After the Arthroscopic Repair of Osteochondral Lesions of the Talus Via Autologous Matrix-induced Chondrogenesis (AMIC)
Italy40 participantsStarted 2026-07-21
Plain-language summary
This clinical study evaluates the long-term, ten-year clinical and functional outcomes of patients who underwent arthroscopic repair of osteochondral lesions of the talus (OLT) using the autologous matrix-induced chondrogenesis (AMIC) technique. Conducted at the IRCCS Ospedale Galeazzi Sant'Ambrogio in Milan, the research addresses a critical gap in current medical literature. While the AMIC procedure is widely utilized to treat these challenging lesions, consolidated very long-term data at the ten-year mark remains scarce. Consequently, this study aims to verify whether the positive clinical benefits previously observed in the short and medium term remain stable over time or if they undergo a significant deterioration. The project will span a total duration of six months, analyzing a sample size of approximately 40 patients who received this specific treatment between April 2013 and April 2016.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
\- Patients who underwent repair of an osteochondral defect via the AMIC® procedure utilizing a porcine collagen I/III membrane (Chondro-Gide®).
Exclusion Criteria:
\- Irrelevant post-operative diagnoses (e.g., pigmented villonodular synovitis) or the inability to retrieve follow-up data.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Ten years follow-up after the arthroscopic repair of osteochondral lesions of the talus via autologous matrix-induced chondrogenesis (AMIC)