Clinical and Radiographic Characteristics and Outcomes of Guided Apicoectomy With Retrograde Mine… (NCT07724964) | Clinical Trial Compass
CompletedNot Applicable
Clinical and Radiographic Characteristics and Outcomes of Guided Apicoectomy With Retrograde Mineral Trioxide Aggregate Filling for Periapical Cysts
Vietnam42 participantsStarted 2025-05-03
Plain-language summary
Patients with periapical cysts associated with premolar teeth often require apical surgery when conventional endodontic treatment cannot resolve the lesion. Guided apicoectomy using a three-dimensional surgical guide may improve surgical accuracy while minimizing bone removal and reducing the risk of damage to adjacent anatomical structures.
This prospective single-arm interventional study aims to evaluate the clinical and radiographic characteristics of premolar teeth with periapical cysts and assess the treatment outcomes of guided apicoectomy with retrograde Mineral Trioxide Aggregate (MTA) filling. Forty-two participants will be treated and followed for six months. Clinical healing and radiographic bone healing will be evaluated one week, three months, and six months after surgery.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults diagnosed with a periapical cyst involving a premolar tooth.
* Diagnosis confirmed by clinical examination and CBCT.
* Histopathological confirmation of periapical cyst after surgery.
* Root canal treatment completed with acceptable obturation quality.
* Tooth considered restorable.
* No previous apicoectomy on the study tooth.
* Able to provide written informed consent.
Exclusion Criteria:
* Uncontrolled systemic diseases.
* Coagulation disorders.
* Uncontrolled diabetes mellitus.
* Active malignancy receiving radiotherapy.
* Severe cardiovascular disease contraindicating surgery.
* Vertical root fracture.
* Grade IV tooth mobility.
* Allergy to local anesthetics or study materials.
* Previous surgery for recurrent periapical cyst at the study site.
* Inability to comply with follow-up schedule.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Treatment Success Rate
Timeframe: 6 months after surgery
Trial details
NCT IDNCT07724964
SponsorCan Tho University of Medicine and Pharmacy