De-escalation of RNI in Breast Cancer Patients With pN0 After Neoadjuvant Therapy (NCT07724769) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
De-escalation of RNI in Breast Cancer Patients With pN0 After Neoadjuvant Therapy
100 participantsStarted 2026-06
Plain-language summary
Prospective Comparative Study of Response-Adapted De-escalation of Regional Nodal Irradiation in Initially Node Positive Breast Cancer Patients with Pathological Nodal Complete Response After Neoadjuvant Therapy
Who can participate
Age range
18 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female patients \>= 18 years old.
* Histologically confirmed invasive breast cancer, cT1-3 N1M0 according to the 8th AJCC edition.
* Biopsy-proven cN1 disease at diagnosis.
* Completion of standard neoadjuvant systemic therapy.
* Surgical treatment of breast and axilla.
* Pathologically confirmed ypN0 status.
* ECOG performance status 0-2.
* Suitable for adjuvant radiotherapy.
* Signed informed consent.
Exclusion Criteria:
* Metastatic disease (M1).
* Prior thoracic irradiation.
* Pregnancy or lactation.
* Severe uncontrolled comorbid illness.
* Any contraindication to radiotherapy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.