The Effectiveness and Safety of Combined Research on Uremic Sarcopenia (NCT07724587) | Clinical Trial Compass
RecruitingNot Applicable
The Effectiveness and Safety of Combined Research on Uremic Sarcopenia
China76 participantsStarted 2025-09-01
Plain-language summary
Objective: To investigate the clinical efficacy and safety of mindfulness meditation during dialysis combined with pre-dialysis progressive resistance training (PRT) for sarcopenia in patients undergoing maintenance hemodialysis (MHD).
Methods: In the randomized controlled trial, 76 MHD patients with sarcopenia were divided into three groups: control group (CG), sports group (SG), and intervention group (IG). All groups received standard dialysis, health education, and dietary guidance. The SG received pre-dialysis PRT, while the IG added mindfulness meditation during dialysis. Efficacy and safety were evaluated at baseline and after 12 weeks. Ultrasound assessments of muscle mass were conducted at baseline, week 4, week 8, and week 12.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Meet the updated Asian diagnostic criteria for sarcopenia
* Stable vital signs and general physical condition
* Willing and able to cooperate with supervised exercise training
* Regular hemodialysis 3 times per week for at least 3 months
Exclusion Criteria:
* Acute cardiovascular or cerebrovascular events within the previous 3 months
* Cognitive dysfunction affecting study cooperation and exercise completion
* Severe osteoarticular or limb movement disorders preventing standardized exercise training
* Active systemic infection
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in 30-second Chair Stand Test (CS30)
Timeframe: 12 weeks
2
Change in Handgrip Strength
Timeframe: 12 weeks
3
Change in 6-Minute Walking Test (6MWT)
Timeframe: 12 weeks
4
Change in Stair Climbing Test
Timeframe: 12 weeks
5
Change in 10-Time Sit-to-Stand Test (TT10SU)
Timeframe: 12 weeks
6
Change in Timed Up and Go Test (TUGT)
Timeframe: 12 weeks
7
Change in skeletal muscle thickness measured by ultrasound
Timeframe: 4 weeks
8
Change in quality of life assessed by standardized scale