Soft and Hard Tissue Healing Following Alveolar Ridge Preservation of Mandibular Third Molar Extr… (NCT07723183) | Clinical Trial Compass
CompletedPhase 4
Soft and Hard Tissue Healing Following Alveolar Ridge Preservation of Mandibular Third Molar Extraction Socket Filled With Auto Tooth Bone Graft or Alloplastic Graft
Malaysia12 participantsStarted 2023-08-01
Plain-language summary
This study compared two bone graft materials: 1. Auto Tooth Bone (ATB) (made from the patient's own extracted tooth) and 2. EthOss® a synthetic alternative. This is to see how well they prevent bone and gum damage after lower wisdom tooth removal. In this split-mouth trial, participants had both lower wisdom teeth removed, with one socket receiving ATB and the other receiving EthOss®. Over a 24-week follow-up period, researchers tracked patient clinically on their comfort, gum healing, and new bone growth using X-rays. The study found that both materials performed similarly and showing no significant differences in pain, swelling, complications, or gum healing. While there was a statistical difference in final bone depth. Both grafts successfully stimulated new bone growth, proving that ATB and EthOss® are equally safe, reliable, and effective options for supporting recovery after wisdom tooth surgery.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patient who requires surgical removal of bilateral impacted M3.
* Patient with impacted bilateral M3 which are sound.
* Impacted bilateral M3 classified as Class I or II with Level A or B according to Pell and Gregory's classification.
* Presence of M2 adjacent to the M3 to be extracted.
* Patient aged 18 to 35 years old.
* Patient with periodontal status of:
* Basic Periodontal Score (BPE) 2 at lower right and lower left sextants.
* Full mouth plaque score \<30%.
Exclusion Criteria:
* Impacted M3 associated in the following conditions:
* Fracture of angle of mandible.
* Radiological evidence of cyst or tumour.
* Incomplete root formation.
* Acute pulpitis or severe pericoronitis that is not under-controlled.
* Gross dental caries.
* Retained roots of mandibular third molar with history of removal of unerupted/impacted M3.
* Patient's age \<18 years old or \> 35 years old
* M2 with periapical inflammation, periodontitis, distal caries or delayed or non-responsive pulp sensibility test to exclude tooth with perio-endo lesion.
* Pregnant woman.
* Patient on oral contraceptives.
* Current or previous bisphosphonate therapy or history of radiotherapy to the jaws.
* Active smoker.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Periodontal health assessment on lower second molar
Timeframe: baseline on day of surgery, 12 weeks and 24 weeks after surgery