CompletedNot Applicable

Effects of Whole Body Vibration Versus Proprioceptive Neuromuscular Facilitation Pattern With Rhythmic Based Training on Clinical Outcomes in Patients With Parkinson's Disease.

Pakistan42 participantsStarted 2026-05-01

Plain-language summary

This study has important clinical, academic, and practical relevance in neuromuscular rehabilitation. Clinically, it aims to identify effective and tolerable rehabilitation strategies for individuals with Parkinson's disease by comparing whole-body vibration therapy with proprioceptive neuromuscular facilitation (PNF) patterns combined with rhythmic-based training, thereby supporting evidence-based physiotherapy practice and improving patient adherence. Academically, it contributes to the limited literature on comparative effectiveness of these interventions and incorporates patient-centered outcomes such as exercise perception, which are often underreported. From a practical and societal perspective, identifying a more acceptable and effective approach may enhance long-term participation in rehabilitation, potentially slow disease progression, improve quality of life, and reduce the overall healthcare burden associated with Parkinson's disease.

Who can participate

Age range

40 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 40 and 60 years. * Patients of both genders (male and female). * Parkinson's disease severity at Hoehn and Yahr (H\&Y) stage 2 and 3. * Ability to walk independently for 6 minutes without an assistive device. * Score greater than 40 on the Berg Balance Scale. Exclusion Criteria: * Presence of impaired Cognition. * Significant Orthopedic and Musculoskeletal conditions that limit the adherence to exercise and WBV requirements. * Other medical conditions like thrombosis, cardiovascular conditions and medical implants that are contradicted for WBV.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Timed Up and Go (TUG) Test

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

Unified Parkinson's Disease Rating Scale - Part III (UPDRS-III)

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

Mini-Balance Evaluation Systems Test (Mini-BESTest)

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

10-Meter Walk Test (10MWT)

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

Trial details

NCT IDNCT07723027

SponsorLahore University of Biological and Applied Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-09

View on ClinicalTrials.gov More Parkinson Disease trials

Plain-language summary

Who can participate

Age range

40 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Timed Up and Go (TUG) Test

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

Unified Parkinson's Disease Rating Scale - Part III (UPDRS-III)

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

Mini-Balance Evaluation Systems Test (Mini-BESTest)

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

10-Meter Walk Test (10MWT)

Timeframe: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]