EndoVascular Aneurysm Repair: Heart Remodeling and Aortic Stiffness Study (NCT07722793) | Clinical Trial Compass
By InvitationNot Applicable
EndoVascular Aneurysm Repair: Heart Remodeling and Aortic Stiffness Study
Croatia60 participantsStarted 2026-07-01
Plain-language summary
Abdominal aortic aneurysm (AAA) is associated with a high burden of cardiovascular morbidity and mortality. Although endovascular aneurysm repair (EVAR) has become the preferred treatment for many patients with infrarenal AAA because of its lower perioperative risk, its impact on arterial stiffness and cardiac function remains insufficiently understood. Experimental and clinical evidence suggests that endograft implantation may increase aortic stiffness by reducing aortic compliance, potentially altering ventricular-arterial coupling and contributing to left ventricular remodeling and dysfunction.
This prospective observational study aims to evaluate the effects of elective EVAR on aortic stiffness, left ventricular structure and function, and circulating biomarkers of myocardial stress and extracellular matrix remodeling. Patients with infrarenal AAA scheduled for elective EVAR will be assessed before the procedure and at 48 hours, 6 months, and 12 months after intervention. Aortic stiffness will be assessed using estimated carotid-femoral pulse wave velocity (cfPWV), while left ventricular function and remodeling will be evaluated by transthoracic echocardiography, including global longitudinal strain (GLS). Circulating NT-proBNP and MMP-3 concentrations will also be measured.
The study will provide insight into the cardiovascular effects of EVAR and may improve understanding of procedure-related changes in arterial stiffness and cardiac remodeling, thereby supporting better long-term cardiovascular risk assessment and postoperative management in patients undergoing EVAR.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients (≥18 years of age) with diagnosed abdominal aortic aneurysm (AAA) who are scheduled for elective endovascular aneurysm repair (EVAR)
* Patients eligible for EVAR according to current clinical guidelines and anatomical criteria
* Signed informed consent for participation in the study
* Ability to undergo scheduled follow-up examinations (baseline, early post-procedural assessment, and follow-up visits)
Exclusion Criteria:
* Emergency EVAR for ruptured or symptomatic abdominal aortic aneurysm
* Previous aortic repair or previous endovascular intervention involving the abdominal aorta
* Concomitant major cardiovascular surgery or intervention during the study period
* Severe hemodynamic instability or critical illness at the time of inclusion
* Active infection or acute inflammatory disease that may influence vascular or inflammatory biomarkers
* Malignancy with active treatment or life expectancy limiting follow-up
* Inability to provide informed consent
* Inability to complete planned follow-up assessments
* Known severe valvular heart disease or advanced heart failure
* Conditions affecting arterial stiffness measurements (e.g. atrial fibrillation, severe arrhythmias, inability to obtain reliable PWV measurements)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is focused on measuring how arterial stiffness and heart remodeling change after EVAR — does my current heart and blood vessel health make me a good candidate to have these measurements tracked meaningfully?
2Since this trial is 'enrolling by invitation,' can you explain how patients are being selected and whether you think I would be eligible to be invited to participate?
3The study is listed as Phase NA, which suggests it may be more of an observational or measurement study rather than a treatment trial — does participating in this study change anything about how my EVAR procedure itself would be performed or managed?
4Since the trial is measuring changes in arterial stiffness and left ventricle remodeling after EVAR, would the additional monitoring or tests involved — like imaging or pressure measurements — add any meaningful burden or risk on top of what I'd already be going through for the procedure?
5Would joining this study affect the timing of my EVAR, and if standard treatment without study participation is also on the table, is there any reason you'd recommend one path over the other for my specific situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in arterial stiffness after endovascular aneurysm repair (EVAR)
Timeframe: Baseline (pre-EVAR) to 12 months after EVAR (2 days, 6 months, 12 months)
Trial details
NCT IDNCT07722793
SponsorJosip Juraj Strossmayer University of Osijek