Bevacizumab, Sintilimab, Cetuximab and Irinotecan in Refractory RAS Wild-type Metastatic Colorect… (NCT07722754) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Bevacizumab, Sintilimab, Cetuximab and Irinotecan in Refractory RAS Wild-type Metastatic Colorectal Cancer: BOND-4 Trial
160 participantsStarted 2026-08-01
Plain-language summary
Primary endpoint: objective response rate Secondary endpoints: PFS, OS and adverse events
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Metastatic and unresectable colorectal adenocarcinom;
* RAS wild-type and MSS tumor;
* Measurable lesions;
* Failed to at least two lines of standard treatment containing fluoropyrimidine, irinotecan and bevacizumab;
* Eastern Cooperative Oncology Group performance status 2 or less;
* White blood cell≥ 3\*10\^9/L, neutrophil≥ 1.5\*10\^9/Lplatelet count≥75\*10\^9/L, hemoglobin≥60g/L;
* Total serum bilirubin≤upper limit of normal (ULN), alanine aminotransferase and aspartate aminotransferase ≤ 2.5\*ULN or ≤5\*ULN for subjects with liver metastasis;
* Creatinine ≤ ULN or creatinine clearance ≥ 80 mL/min;
* Urinary protein negative or 24-hour urinary protein ≤ 2g;
* Activated partial thromboplastin time≤ULN and international normalized ratio≤1.5;
* Any major surgery ≥ 4 weeks and any minor surgery ≥ 1 week and fully recovered from the procedure;
* Life expectancy \> 3 months;
* Provide fully informed written consent;
Exclusion Criteria:
* Other aggressive malignancies within 3 years (Exceptions: non-melanoma skin cancer or carcinoma-in-situ of the cervix that has been treated);
* Allergy or intolerance to any of the study drugs;
* Human immunodeficiency virus positive;
* Concurrent anti-cancer therapy including radiation therapy, chemotherapy, targeted agents or biological agents not otherwise specified within two weeks;
* Malignant bowel obstruction;
* Prior treatment with PD-1 antibody;
* Autoimmune diseases;
* Significant bleeding events or pre-existin…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.