TeleStroke-Guided Thrombolysis for Acute Ischemic Stroke in Oman (NCT07721129) | Clinical Trial Compass
Not Yet RecruitingPhase 4
TeleStroke-Guided Thrombolysis for Acute Ischemic Stroke in Oman
200 participantsStarted 2026-08-01
Plain-language summary
The goal of this study is to establish and examine the efficacy of using a Telestroke network in Oman to facilitate using emergent thrombolysis for patients with acute ischemic stroke encountered in selected peripheral hospitals. It is proposed to establish a TeleStroke network involving two central hospitals in Muscat linked to three to five peripheral hospitals in Oman which currently have access to CT scans and basic infrastructure for management of AIS patients- but do not have a Neurology service. Selected staff from Internal Medicine/Emergency Medicine departments, Nursing, Technical service and support staffs will be trained in the process of assessment and management of AIS patients including the use of IV alteplase or tenecteplase. They will also be trained in timely access of a Neurologist on call at the central hospital(s) using a TeleStroke network. The Neurologist would conduct a Telestroke based clinical assessment of the AIS patient, review imaging and laboratory results in a timely manner and advice the medical team at the peripheral hospital regarding administration of IV alteplase/tenecteplase. The main purpose of such consultation would be to recognize eligible patients for administration of IV thrombolysis safely at the earliest opportunity within 4.5 hours, leading to increased rates of such thrombolysis with expected improved outcomes. Outcomes would be compared among 100 patients with AIS managed across these 5 hospitals prior to initiation of the practice of thrombolysis and at least 100 patients treated each with IV alteplase using TeleStroke Consultation with Neurologist. Demonstration of efficacy of TeleStroke based stroke thrombolysis would lead to effective implementation of this practice in Oman.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age \>18 years. Acute neurologic deficits due to cerebral ischemia/infarction. Clearly defined onset with duration from stroke onset of \<4.5 hours. Significant neurological deficit (usually NIHSS score of 4-25).
Exclusion Criteria:
* CT brain shows showing evidence of intracranial hemorrhage
* CT brain showing acute or subacute infarct of size about \>1/3 Middle Cerebral Artery territory.
* Arterial puncture at non compressible site in previous 7 days
* History of previous intracranial hemorrhage.
* Intracranial neoplasm, AV malformation, or aneurysm
* Recent head injury OR intracranial or intraspinal surgery in last 3 mo.
* Persistent Elevated BP \>185/110 mm Hg despite treatment.
* Active ongoing internal bleeding.
* Platelet count \<100 000/mm3.
* Current use of NOACs OR warfarin with INR \>1.7 OR Inj.Enoxaparin/Heparin in therapeutic dose
* Blood glucose concentration \<2.7mmol/L (\<50mg/dl).
Relative contraindications: (may consider IV alteplase on individual evaluation).
* Seizure at onset with post ictal residual neurological deficit.
* Signs of mild stroke in isolation or rapidly improving symptoms.
* Pregnancy.
* Recent GI or UT hemorrhage within the last 21 days.
* Recent MI within previous 3 months (to exclude anterolateral infarct / STEMI)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
90 day outcome
Timeframe: 90 days
2
Discharge Outcome
Timeframe: At discharge (assessed up to 5 days)
3
Rate of Thrombolysis
Timeframe: At admission and initial management- 2 hours