The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Succe… (NCT07721051) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment
60 participantsStarted 2026-10-01
Plain-language summary
This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.
Participants will be randomly assigned to one of four groups based on the scaffold used: induced blood clot, injectable platelet-rich fibrin (i-PRF), advanced platelet-rich fibrin (A-PRF), or advanced platelet-rich fibrin plus (A-PRF+). All participants will receive the same root canal disinfection and restorative procedures, with the scaffold type differing between the groups.
Participants will be evaluated clinically and radiographically at 3, 6, and 12 months after treatment. The study will compare the groups in terms of the resolution of clinical signs and symptoms and changes observed on radiographic and cone-beam computed tomography images.
Who can participate
Age range
16 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 16-40 who are systemically healthy
* Patients who have a permanent tooth with a single root canal and fully developed root that requires retreatment
* Patients who may or may not have periapical radiolucency
Exclusion Criteria:
* Patients who require antibiotic prophylaxis
* Patients with systemic conditions such as diabetes or hematological disorders
* Patients who have taken antibiotics, anti-inflammatory medications, and/or antidepressants within the past three weeks
* Patients who are pregnant or suspect they may be pregnant during treatment
* Patients with heavy plaque and tartar buildup on their teeth
* Patients with redness and bleeding of the gums
* Patients with severe gingivitis, generalized periodontitis, or a periodontal pocket depth of more than 3 mm
* Patients with internal or external root resorption
* Patients for whom complete isolation with a rubber dam cannot be achieved
* Patients with an open, immature root apex
* Patients with horizontal or vertical fractures
* Patients with teeth having multiple roots or root canals
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of Teeth Achieving Clinical and Radiographic Success at 12 Months