Salivary Function and Dental Changes During GLP-1 Therapy (NCT07720466) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Salivary Function and Dental Changes During GLP-1 Therapy
Turkey (Türkiye)40 participantsStarted 2026-08-17
Plain-language summary
People who use glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide and tirzepatide, may experience changes in their oral health. Some people report dry mouth, changes in saliva, and increased wear of their teeth after starting these medicines. However, little is known about whether these medicines affect saliva and dental hard tissues.
The purpose of this study is to evaluate changes in salivary calcium levels, salivary function, and dental hard tissues in adults who begin treatment with semaglutide or tirzepatide for obesity.
Approximately 40 participants will be enrolled before starting GLP-1 receptor agonist therapy. Oral examinations, standardized intraoral photographs, saliva samples, and body weight measurements will be obtained before treatment and again after three months. Saliva samples will be analyzed for calcium concentration, pH, and salivary flow rate. Dental hard tissue changes will be assessed using the Basic Erosive Wear Examination (BEWE) index.
The findings from this study may improve understanding of the effects of GLP-1 receptor agonists on oral health and help healthcare professionals identify and prevent possible dental complications during treatment.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 years or older.
* Body mass index (BMI) ≥27 kg/m².
* Clinical decision by an endocrinologist to initiate semaglutide or tirzepatide therapy for obesity management.
* No previous treatment with GLP-1 receptor agonists.
* Willingness to participate and ability to provide written informed consent.
* Willingness to attend both the baseline and 3-month follow-up visits.
Exclusion Criteria:
* Previous use of any GLP-1 receptor agonist.
* History of head and neck radiotherapy.
* Sjögren syndrome or other systemic diseases affecting salivary gland function.
* Chronic kidney disease.
* Pregnancy or breastfeeding.
* Use of medications known to markedly affect salivary secretion.
* Active orthodontic treatment.
* Severe dental erosion requiring restorative treatment at baseline.
* Edentulism or the absence of anterior teeth required for dental hard tissue assessment.
* Inability or unwillingness to comply with the study protocol or attend the 3-month follow-up visit.
* History of eating disorders associated with recurrent self-induced vomiting (e.g., bulimia nervosa).
* Medical conditions causing persistent vomiting or severe gastroesophageal disease unrelated to GLP-1 therapy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.