Not Yet RecruitingNot Applicable

Treatment Costs of Kidney Injury in Patients Having Heart Surgery in the UK

United Kingdom4,600 participantsStarted 2026-10-01

Plain-language summary

Single-centre retrospective analysis of prospectively collected data with propensity matched scoring groups (AKI v/s non-AKI). Data collection from databases (or their equivalent): PATS Dendrite, Electronic Medical Records, TD-web (results Portal), MedTrack (ICU database), iSite (Radiology), SPY (Long-term status)

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Underwent elective or in-house urgent cardiac surgery at the Royal Wolverhampton NHS Trust between 1st January 2013 and 31st December 2025, excluding those who had surgery during 2020 and 2021 due to the confounding effect of COVID-19 on acute kidney injury incidence. * Cardiopulmonary bypass (CPB) was utilised during the cardiac surgical procedure. * A complete minimum dataset is available within the study databases, comprising: age, sex, history of diabetes, left ventricular ejection fraction (LVEF), surgical priority, pre-operative haemoglobin and serum creatinine (SCr) levels, type of cardiac surgery performed, CPB duration, EuroSCORE or logistic EuroSCORE, renal replacement therapy (RRT) use, and post-operative day 1 and/or day 2 and/or day 3 SCr values. Exclusion Criteria: * The procedure was performed as an emergency surgery. * Required data fields are incomplete or unavailable. * Surgery was performed off-pump, without the use of cardiopulmonary bypass. * The patient was dialysis-dependent prior to surgery. * The patient had a pre-operative estimated glomerular filtration rate (eGFR) of less than 20 mL/min/1.73 m². * The cardiac procedure required deep hypothermic circulatory arrest (DHCA). * The patient has exercised their right to opt out of research data use.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is measuring the overall treatment costs for different stages of kidney injury after heart surgery — does that mean it's purely an observational cost study, and if so, would joining it change anything about the care I receive or just involve tracking my medical expenses?
2Since this study is not yet recruiting, do you know when it's expected to open and whether this hospital is likely to be one of the participating sites in the UK?
3The trial focuses on acute kidney injury that happens as a complication of cardiac surgery — given my specific heart condition and overall kidney health, how likely is it that I might develop this kind of kidney injury, and does that affect which surgical approach you'd recommend for me?
4Because this appears to be an economic data-collection study rather than a treatment trial, are there any actual treatment studies for cardiac surgery-related kidney injury that you think I should also be aware of as I plan my care?
5If I were enrolled in this study and did develop kidney injury after surgery, would the KDIGO staging system used here influence the treatment decisions your team makes, or is that already standard practice regardless of the study?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Overall cost of treatment in £ for the each KDIGO stage of CSA-AKI

Timeframe: From date each patient had surgery to the date each patient discharged from hospital, for all eligible patients who underwent surgery between 1st January 2013 and 31st December 2025 (varies from patient to patient), assessed at point of data extraction

Trial details

NCT IDNCT07719569

SponsorThe Royal Wolverhampton Hospitals NHS Trust

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2027-04-01

View on ClinicalTrials.gov More Acute Kidney Injury trials