Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliat… (NCT07719101) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome
Croatia70 participantsStarted 2026-07-20
Plain-language summary
Pseudoexfoliation syndrome is associated with alterations in the biomechanical properties of the cornea. This prospective observational cohort study aims to evaluate changes in corneal biomechanical properties after standard phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome compared with patients without pseudoexfoliation syndrome. Corneal hysteresis (CH) and corneal resistance factor (CRF) will be measured using the Ocular Response Analyzer before surgery and at postoperative day 1, day 7, and day 30. The study will enroll patients undergoing routine cataract surgery to compare postoperative changes in CH and CRF between the pseudoexfoliation and control groups.
Who can participate
Age range
50 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* adults aged 50 years and older
* presence of age-related cataract requiring phacoemulsification cataract surgery
* presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group)
* ability and willingness to provide written consent
Exclusion Criteria:
* previous ocular surgery,
* corneal disease,
* glaucoma or ocular hypertension,
* dry eye disease (Schirmer test \<10 mm, tear break-up time \<5 seconds or positive fluorescein staining),
* high refractive error (myopia \> -6.00 D or hyperopia \> +5.00 D),
* unilateral pseudoexfoliation when the eye scheduled for surgery showed Adults no signs of PEX,
* intraoperative or postoperative complications,
* any ocular disease that could influence corneal biomechanics
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in corneal hysteresis (CH)
Timeframe: Baseline, postoperative day 1, day 7 and day 30