Active — Not RecruitingNot Applicable

Comparative Effects of SBES Versus TOT on Lower Limb Motor Function in Post-Stroke Patients

Pakistan32 participantsStarted 2026-06-05

Plain-language summary

Stroke-induced lower limb impairments severely inhibit functional independence and mobility in survivors. Inventive techniques like Synergy-Based Electrical Stimulation (SBES) and Task-Oriented Training (TOT) support favorable rehabilitation results based on Neuroplasticity. This study aims to compare the effectiveness of these in restoring purposeful movements and enhancing motor functions in post-stroke patients.This study aims to compare the efficacy of (SBES) and Task-Oriented Training (TOT) in improving lower limb motor control in sub-acute post-stroke patients. This study will be a single-blinded randomized clinical trial design. Participants, aged 40-60 will be recruited in this study by Non-Probability convenience sampling from Rehabilitation centers and Neurology departments. Informed consent and consistent attendance throughout the intervention will be required. Through the computerized table generator method of randomization, participants will be evenly divided into two groups. Both groups will receive conventional therapy, like stretching, strengthening, and isometrics, with modalities. Group A will receive 30 Hz electrical stimulation on the affected lower limb muscles (hip flexors, knee flexors, and ankle dorsiflexors) in a synergic pattern, for 60 minutes, thrice weekly for 6 weeks. Group B will engage in functional tasks for 60 minutes, thrice weekly for 6 weeks, repeated 10 times per set with 2 sets of each activity, plus an additional self-practice session. Outcome measures will be assessed at baseline and post-intervention stages by the Fugl-Meyer Assessment for motor recovery, Time UP and Go Test (TUG) and 10 Meter Walk Test for functional mobility, gait, and balance. The paired sample t-test will be used for within-group analysis in the parametric data and the Wilcoxon test for non-parametric data, whereas, for between-group analysis independent t-test will be used for parametric data and Mann Whitney U test will be used for non-parametric data. Statistical analysis will be done by using SPSS version 26. Keywords: Lower Limb, motor control, SBES, Strength, Stroke, TOT.

Who can participate

Age range

40 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 40 to 60 years * Both Male and Female participants * In the sub-acute phase of stroke (1-6 months post-stroke) with lower limb motor impairment but with the ability to initiate at least trace muscle contraction (Grade ≥ 1). * Participants must have the ability to understand and follow simple verbal commands with the Mini-Mental State Examination (MMSE) ≥ 26. * Participants must have a first-ever ischemic and hemorrhagic stroke in the sub-acute stage. * Participants who are functionally ambulatory and able to walk a minimum of 10 feet, with or without the use of assistive devices with a Functional Ambulation Category (FAC) score ≥ 2. Exclusion Criteria: * Participants have severe cognitive impairment and an inability to understand or follow instructions, and severe sensory impairment with profound sensory loss in the lower limb affecting balance or feedback-based training. * Participants having orthopedic limitations like recent fractures, joint deformities, or surgeries affecting the lower limbs. * Participants having implanted electrical devices like pacemakers are contraindicated for electrical stimulation * Participants having a history of more than one stroke episode and or multiple infarcts.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Fugl-Meyer Assessment:

Timeframe: Baseline to 4 weeks

The Timed Up and Go (TUG) Test

Timeframe: Baseline to 4 weeks

10-Meter Walk Test

Timeframe: Baseline to 4 weeks

Trial details

NCT IDNCT07718776

SponsorRiphah International University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-06

View on ClinicalTrials.gov More Post Stroke trials

Plain-language summary

Who can participate

Age range

40 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.