Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery (NCT07718373) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
5,000 participantsStarted 2026-07-20
Plain-language summary
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
·adults admitted to the ICU after CPB-assisted cardiac surgery
Exclusion Criteria:
* congenital heart disease,
* surgery requiring deep hypothermic circulatory arrest,
* a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²,
* AKI already present prior to ICU admission
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing L-arginine after cardiac surgery to see if it affects acute kidney injury — is L-arginine something my doctor would consider a low-risk supplement, or are there specific risks I should know about given my heart and kidney health?
2Since this trial is listed as 'not yet recruiting,' how long might it be before it actually opens and starts enrolling patients, and would waiting for it affect my treatment timeline?
3The trial is listed as Phase NA, which can mean it's not a traditional drug trial — can my doctor explain what that means for how much is already known about the safety and effectiveness of using L-arginine this way after cardiac surgery?
4If I'm having cardiac surgery, what is my current risk for developing acute kidney injury afterward, and is that risk level the kind this trial seems designed to address?
5Are there standard-of-care approaches already used to reduce acute kidney injury after cardiac surgery that I should consider first, before thinking about whether a trial like this might be relevant to my situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.