Active — Not RecruitingNot Applicable

Trifecta Research Study

United States52 participantsStarted 2022-08-01

Plain-language summary

This observational study evaluates the impact of Ibogaine-Magnesium (IM), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), Magnetic e-Resonance Therapy (MeRT), and Physiological Supplementation (PS) on posttraumatic stress disorder (PTSD) and traumatic brain injury-related cognitive symptoms among Special Operations Forces (SOF) combat veterans.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 18 years of age * Sponsored by SOC-F Program Exclusion Criteria (evaluated by SOC-F, not Axial Therapeutic Research): * Diagnosis of Schizophrenia, Bipolar I or II disorder for which patient has been hospitalized or medicated, Depersonalization and/or Derealization Disorder * Cerebellar dysfunction, Epilepsy, Psychosis or acute confusional state, Dementia * Prolonged corrected QT interval (QTc) Interval (450ms in males; 470ms in females) * History of heart failure or hypertrophic heart * Active blood clots (e.g., Pulmonary embolism, Deep vein thrombosis) * Major respiratory conditions (e.g., Emphysema, Cystic fibrosis) * Severe chronic gastrointestinal issues (e.g., bleeding ulcer, leaky gut syndrome) * Within 6 months of surgeries * Abnormal blood test results (e.g., potassium or magnesium outside normal range) * Impaired kidney or liver function * Refusal to taper off of selective serotonin reuptake inhibitor (SSRI) medication

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

PTSD Checklist for Diagnostic and Statistical Manual (DSM)-5 (PCL-5)

Timeframe: Up to 12 months follow up

Medical Outcomes Study Cognitive Functioning Scale (MOS-CF)

Timeframe: Up to 12 months follow up

Stroop Squared Task

Timeframe: Up to 12 months follow-up

Externalized Free Recall with Emotional Words Task

Timeframe: Up to 15 weeks (Post-MeRT for Group A, Post-IM/5MeO for Group B)

Trial details

NCT IDNCT07717866

SponsorAxial Therapeutic Research

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2026-02-01

View on ClinicalTrials.gov More PTSD - Post Traumatic Stress Disorder trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

PTSD Checklist for Diagnostic and Statistical Manual (DSM)-5 (PCL-5)

Timeframe: Up to 12 months follow up

Medical Outcomes Study Cognitive Functioning Scale (MOS-CF)

Timeframe: Up to 12 months follow up

Stroop Squared Task

Timeframe: Up to 12 months follow-up

Externalized Free Recall with Emotional Words Task

Timeframe: Up to 15 weeks (Post-MeRT for Group A, Post-IM/5MeO for Group B)