Time to Loss of Consciousness With Remimazolam Versus Propofol for Anesthetic Induction in Laparo… (NCT07717684) | Clinical Trial Compass
RecruitingPhase 4
Time to Loss of Consciousness With Remimazolam Versus Propofol for Anesthetic Induction in Laparoscopic Cholecystectomy
Brazil66 participantsStarted 2026-08
Plain-language summary
The goal of this clinical trial is to compare two medicines used to induce general anesthesia in adults undergoing elective laparoscopic cholecystectomy. The study aims to determine whether remimazolam leads to a different time to loss of consciousness than propofol.
The main question it aims to answer is: Does remimazolam change the time to loss of consciousness compared with propofol during anesthesia induction?
Researchers will compare remimazolam with propofol to evaluate the time required for participants to lose consciousness. The study will also compare blood pressure, heart rate, and other safety outcomes during anesthesia induction.
Participants will:
* Be randomly assigned to receive either remimazolam or propofol for anesthesia induction.
* Receive standard monitoring and anesthesia care throughout surgery.
* Have their time to loss of consciousness, vital signs, and any adverse events recorded during the induction period.
Who can participate
Age range
18 Years – 49 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18 years or older.
* American Society of Anesthesiologists (ASA) physical status I or II.
* Scheduled to undergo elective laparoscopic cholecystectomy under Total Intravenous Anesthesia (TIVA).
Exclusion Criteria:
* Patients younger than 18 years or older than 50 years
* American Society of Anesthesiologists (ASA) physical status III to V
* Body Mass Index (BMI) \< 17.5 kg/m² or \> 30 kg/m²
* Hemodynamically unstable patients
* Altered or impaired renal or hepatic function
* Neuromuscular disorders
* History of alcohol or drug dependence
* History of allergy or hypersensitivity to any of the anesthetic medications utilized in the protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time to Loss of Consciousness (TLOC)
Timeframe: From the initiation of the hypnotic agent infusion until the achievement of loss of consciousness (estimated time frame of up to 5 minutes during the anesthesia induction phase).