RecruitingNot Applicable

Blood Flow Restriction During Nordic Hamstring Exercise in Elite Adolescent Athletes

Turkey (Türkiye)24 participantsStarted 2026-07-01

Plain-language summary

This crossover experimental study aims to compare acute hamstring muscle oxygenation responses during Nordic Hamstring Exercise (NHE) and Blood Flow Restriction Nordic Hamstring Exercise (BFR-NHE) in elite adolescent athletes. Participants will complete both exercise conditions in a randomized order separated by a 7-day washout period. Muscle oxygen saturation will be assessed using near-infrared spectroscopy (MOXY), together with total hemoglobin responses, blood lactate concentration, perceived exertion, and exercise performance variables. The findings may improve understanding of the physiological effects of blood flow restriction during eccentric hamstring exercise in adolescent athletes.

Who can participate

Age range

14 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Elite adolescent athletes aged 14 to 18 years. * Licensed athletes with at least 3 years of regular sports participation. * Currently participating in a regular weekly training program. * Physically able to complete the Nordic Hamstring Exercise and study testing protocol. * Willing to participate in the study. * Able to provide written informed consent. * For participants younger than 18 years, written informed consent provided by a parent or legal guardian and assent provided by the participant. Exclusion Criteria: * Hamstring injury within the previous 6 months. * Lower extremity surgery within the previous 6 months. * Current lower extremity pain or musculoskeletal injury that may interfere with exercise performance. * Cardiovascular, vascular, neurological, or other medical conditions that may contraindicate blood flow restriction exercise. * Presence of skin lesions or conditions preventing placement of the blood flow restriction cuff or MOXY sensor. * Inability to complete either exercise condition or follow the study protocol.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference in Change in Hamstring Muscle Oxygen Saturation (Delta SmO₂) Between NHE and BFR-NHE

Timeframe: During each exercise session, with the two sessions separated by a 7-day washout period

Difference in Minimum Hamstring Muscle Oxygen Saturation Between NHE and BFR-NHE

Timeframe: During each exercise session, with the two sessions separated by a 7-day washout period

Difference in Hamstring Muscle Oxygen Saturation During Recovery Between NHE and BFR-NHE

Timeframe: Immediately after each exercise session during the recovery period, with sessions separated by a 7-day washout period

Difference in Peak Hamstring Total Hemoglobin Between NHE and BFR-NHE

Timeframe: During each exercise session, with the two sessions separated by a 7-day washout period.

Difference in Change in Hamstring Total Hemoglobin Between NHE and BFR-NHE

Timeframe: During each exercise session, with the two sessions separated by a 7-day washout period.

Difference in Post-Exercise Blood Lactate Concentration Between NHE and BFR-NHE

Timeframe: Immediately after each exercise session, with the two sessions separated by a 7-day washout period

Trial details

NCT IDNCT07715786

SponsorToros University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-07

Contact for this trial

İdil Ünlü, Assist. Prof. Dr.

+90 506 515 66 22 idil.unlu@toros.edu.tr

View on ClinicalTrials.gov More Healthy Volunteers (HV) trials