Triamcinolone Nanocapsules After Endoscopic Nasal Surgery (NCT07714525) | Clinical Trial Compass
RecruitingPhase 2
Triamcinolone Nanocapsules After Endoscopic Nasal Surgery
Egypt50 participantsStarted 2026-05-01
Plain-language summary
This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery.
Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Adults aged 18 to 60 years.
* Patients scheduled to undergo one of the following procedures:
* Functional endoscopic sinus surgery
* Endoscopic turbinoplasty
* Endoscopic septoplasty
* Diagnosis of chronic rhinosinusitis and/or nasal polyps requiring surgical intervention.
* Ability and willingness to provide written informed consent.
* Ability and willingness to comply with study treatment and scheduled follow-up visits.
Exclusion Criteria
* Known hypersensitivity to triamcinolone acetonide.
* Known hypersensitivity to any component of the polymeric nanocapsule formulation.
* Systemic contraindication to corticosteroid therapy.
* Active severe nasal or sinonasal infection at the time of enrollment or treatment.
* Pregnancy or breastfeeding, if excluded in the approved protocol.
* Uncontrolled diabetes mellitus, if corticosteroid exposure is considered clinically relevant.
* Immunosuppression or use of immunosuppressive therapy.
* Recent use of systemic or intranasal corticosteroids within the protocol-defined washout period.
* Participation in another clinical trial.
* Any medical or psychiatric condition that may interfere with informed consent, study treatment, or follow-up.
* Inability to complete the required questionnaires or follow-up visits.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.