Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients… (NCT07714018) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients With Small Renal Masses on Active Surveillance
United States20 participantsStarted 2026-09-01
Plain-language summary
This clinical trial compares two different weight-loss programs, daily continuous calorie energy reduction (CER) versus (vs.) 5:2 intermittent fasting (IF), in preventing progression of kidney (renal) cancer among patients with one or more small renal masses (SRM) undergoing active surveillance (AS). Kidney cancer patients tend to have changes in metabolism that may increase body weight, but weight-loss strategies that work for best for these patients are unknown. The CER program requires a set daily limit for calories. The IF program requires fasting for 2 days a week and normal eating for the remaining 5 days. Both will include self-monitoring with interventionist feedback. This trial may help researchers determine whether the IF program works better than the CER program in improving weight loss, physical health, and/or reducing the risk of kidney cancer progression among patients with small renal masses undergoing AS
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* English speaking
* SRM patient with biopsy-confirmed RCC who are initiating or already on AS for less than 5 years
* Age 18 years or older
* Body mass index (BMI) ≥ 25 kg/m\^2
* No medical problems that might contraindicate participation in a behavioral weight reduction program containing an exercise component
* No current medication that might affect weight loss
* Not pregnant or lactating
* No more than 5% body weight loss in the past 3 months
* No bariatric surgery in the last 10 years
Exclusion Criteria:
* Non-English speaking
* Less than 18 years old
* BMI \< 25 kg/m\^2
* Medical problems that might contraindicate participation in a behavioral weight reduction program containing an exercise component
* Current medication that might affect weight loss
* Pregnant or lactating
* More than 105% body weight loss in the past 6 months
* Bariatric surgery in the last 10 years
* Medical conditions that might contraindicate short-term fasting periods
* Unwilling or unable to follow protocol requirements
* Received an investigational agent within 30 days prior to enrollment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.