CompletedNot Applicable

Titanium-Prepared Platelet-Rich Fibrin for Extraction Socket Healing

Turkey (Türkiye)30 participantsStarted 2023-03-01

Plain-language summary

Alveolar ridge preservation after tooth extraction is important for maintaining bone volume and facilitating future implant placement. Titanium-prepared platelet-rich fibrin (T-PRF) is an autologous platelet concentrate that may enhance soft and hard tissue healing through the sustained release of growth factors. However, clinical evidence regarding its effect on socket healing remains limited. The aim of this prospective randomized controlled clinical trial is to evaluate the effect of T-PRF on alveolar socket healing following tooth extraction. Participants requiring tooth extraction and subsequent implant placement are randomly assigned to either a T-PRF group or a spontaneous healing (control) group. Cone-beam computed tomography (CBCT) is used to evaluate socket healing volumetrically. The primary outcome is the percentage of socket fill and residual non-ossified socket volume after 3 months. Secondary outcomes include baseline socket volume and postoperative clinical healing. The findings of this study are expected to provide evidence regarding the effectiveness of T-PRF in enhancing alveolar socket healing and preserving ridge dimensions before implant placement.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 to 65 years. * Systemically healthy individuals. * Indication for tooth extraction followed by implant placement. * Adequate bone volume for future implant placement without the need for advanced augmentation procedures. * Good oral hygiene (Plaque Index ≤1.5) * Ability and willingness to provide written informed consent. Exclusion Criteria: * Current smokers. * Pregnant or breastfeeding women. * Uncontrolled systemic disease or diabetes mellitus. * Use of medications known to affect bone metabolism. * History of head and neck radiotherapy or chemotherapy. * Acute infection, periapical lesions, alveolar bone pathology, or socket defects at the extraction site. * Severe periodontal destruction requiring extensive augmentation procedures. * Inability or unwillingness to attend scheduled follow-up visits.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percentage of Socket Fill

Timeframe: 3 months after tooth extraction

Percentage of Socket Fill

Timeframe: 3 months after tooth extraction

Trial details

NCT IDNCT07712497

SponsorEskisehir Osmangazi University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-29

View on ClinicalTrials.gov More TEETH EXTRACTION trials