Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerv… (NCT07712419) | Clinical Trial Compass
RecruitingNot Applicable
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
Turkey (Türkiye)30 participantsStarted 2026-05-15
Plain-language summary
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably. Identifying imaging biomarkers that predict clinical response may improve patient selection and optimize treatment outcomes.
This prospective observational study aims to evaluate whether the Sonographic Thigh Adjustment Ratio (STAR), calculated as anterior quadriceps muscle thickness divided by body mass index (BMI), and subcutaneous fat thickness are associated with pain relief following genicular nerve block in patients with symptomatic knee osteoarthritis. Ultrasound measurements will be obtained before the procedure, and clinical outcomes will be assessed during follow-up. The primary objective is to determine whether sonographic muscle parameters can predict treatment response after GNB.
Who can participate
Age range
45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥45 years.
* Symptomatic bilateral knee osteoarthritis with Kellgren-Lawrence grade 3 or 4.
* Visual Analog Scale (VAS) pain score ≥4 at rest or during movement.
* Scheduled to undergo first ultrasound-guided genicular nerve block.
* No intra-articular knee injection within the previous 3 months.
* Considered unsuitable for or awaiting total knee arthroplasty.
* Ability to provide written informed consent.
Exclusion Criteria:
* Inflammatory arthritis, rheumatoid arthritis, or crystal arthropathy.
* Previous knee surgery or knee prosthesis.
* Active local or systemic infection.
* Anticoagulant therapy or bleeding disorders.
* Contraindication to corticosteroids (including uncontrolled diabetes mellitus).
* Allergy to study medications.
* Neurological disorders causing neuropathic knee pain.
* Dementia or inability to complete study assessments.
* Additional interventional procedures or surgery during follow-up.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Treatment Response at 1 Month Following Genicular Nerve Block
Timeframe: 1 month
Trial details
NCT IDNCT07712419
SponsorGaziosmanpasa Research and Education Hospital