CompletedNot Applicable

Effect of GMI With and Without NM on LE in Cancer Patients With CIPN

Pakistan48 participantsStarted 2025-03-01

Plain-language summary

The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients. The main questions it aims to answer are: \- Does graded motor imagery yields any added effects in relieving nerve related symptoms due to chemotherapy in lower limbs of cancer patients to the effects of nerve mobilization? Researchers will compare the effects of graded motor imagery as a standalone therapy (Group A) to the effects of graded motor imagery with nerve mobilization (Group B) Participants will take treatment sessions according to their allocated group, two sessions per week for six weeks.

Who can participate

Age range

31 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Both male and female * Age ranging from 31 to 65 years * Diagnosed cancer patients (stage 1 to 3, cancer of any kind) * Chemotherapy sessions (antineoplastic drugs) - at least 1 session * Presence of glove and stocking peripheral neuropathy * LANSS score greater than 12 * Agreed to give complete follow-up Exclusion Criteria: * Any co-morbid conditions that can cause peripheral neuropathy e.g. diabetes, chronic kidney failure * Any trauma history that can cause peripheral neuropathic symptoms * Pre-existing nerve entrapment syndromes * Diagnosed stage 4 cancer patients * Cancer patients taking palliative chemotherapy

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

LANSS

Timeframe: Baseline, week 3 (mid-intervention), week 6 (post intervention)

Trial details

NCT IDNCT07712302

SponsorUniversity of Faisalabad

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-06

View on ClinicalTrials.gov More Chemotherapy Induced Peripheral Neuropathy (CIPN) trials