The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults. Ketones are naturally produced by the body during periods of fasting or carbohydrate restriction and serve as an alternative fuel source for the brain. Researchers are interested in whether increasing blood ketone levels through supplementation can alter brain activity and blood flow in ways that may support healthy brain function. Participants will consume a ketone ester supplement and a placebo in separate study visits. Brain imaging, blood measurements, and cognitive testing will be used to evaluate the effects of each intervention. Findings from this study will help researchers better understand how ketones influence the healthy aging brain and may provide preliminary data for future studies in populations at risk for cognitive decline.
Age range
45 Years – 65 Years
Sex
ALL
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Cerebral Blood Flow
Timeframe: Acute response following 2-day lead in
Brain Glutamate Concentration
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Brain GABA Concentration
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Brain Lactate Concentration
Timeframe: Acute response following 2-day lead in
Brain Choline Concentration
Timeframe: Acute response following 2-day lead in
Brain N-Acetylaspartate (NAA) Concentration
Timeframe: Acute response following 2-day lead in
Brain Glucose Concentration
Timeframe: Acute response following 2-day lead in
Brain Beta-Hydroxybutyrate (BHB) Concentration
Timeframe: Acute response following 2-day lead in
Functional Brain Connectivity
Timeframe: Acute response following 2-day lead in
Brain Acetoacetate Concentration
Timeframe: Acute response following 2-day lead in
Brain Glutamine Concentration
Timeframe: Acute response following 2-day lead in