Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children (NCT07710482) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
Egypt40 participantsStarted 2026-08-01
Plain-language summary
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026 to Mars 2027.
Aim of the study will be:
1. Compare the incidence of clinically significant catheter-related complications (catheter occlusion requiring intervention or catheter-related thrombosis) within 14 days after CVL insertion between children receiving prophylactic anticoagulation and those receiving standard care.
2. Compare time-to- first catheter occlusion.
3. Compare rate of catheter-related bloodstream infection (CLABSI) within 30 days.
4. Compare number of catheter manipulations and unplanned catheter removals.
5. Compare major and minor bleeding events.
6. Assess catheter dwell time and need for thrombolysis or therapeutic anticoagulation.
Who can participate
Age range
1 Month – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* All Children requiring a newly placed central venous line (peripherally inserted central catheter \[PICC\], or non-tunneled central venous catheter) for clinical care.
Exclusion Criteria:
* Known major congenital bleeding diathesis or platelet count \<50,000/µL at time of insertion.
* Already on therapeutic anticoagulation for another indication.
* Known heparin allergy or history of heparin-induced thrombocytopenia.
* Use of dialysis catheters (study focuses on standard CVCs/PICCs).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.