The goal of this observational study is to identify progressive changes of quantitative brain and lung imaging, serum and movement-related biomarkers reflecting disease progression in pre-symptomatic infants and very young children (0-5 yo) with a genetic diagnosis of A-T, that could be used in future early-life intervention trials.
Age range
0 Years – 5 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Brain MRI - Volumetric structural T1-weighted (T1)
Timeframe: Up to 4 years ( last visit)
Brain MRI - Magnetic Resonance Spectroscopy (MRS): quantification of N-acetyl aspartate in the cerebellum
Timeframe: Up to 4 years ( last visit)
Brain MRI - Diffusion Weighted Imaging (DWI)
Timeframe: Up to 4 years ( last visit)
Neurological and developmental assessment
Timeframe: Up to 4 years ( last visit)
Quantitative movement analysis
Timeframe: Up to 4 years ( last visit)
Serum markers of neurodegeneration
Timeframe: Up to 4 years ( last visit)