CompletedNot Applicable

The Effects of Whole-Body Vibration Training on Clinical and Functional Outcomes in Individuals Diagnosed With Interstitial Lung Disease

Turkey (Türkiye)26 participantsStarted 2026-01-15

Plain-language summary

This randomized controlled trial aims to investigate the clinical and functional effects of Whole Body Vibration (WBV) training when added to a standard pulmonary rehabilitation (PR) program in patients with fibrotic interstitial lung disease (ILD). Participants aged between 40 and 80 years with confirmed ILD diagnosis will be randomly assigned to two groups: (1) PR only (control), and (2) PR + WBV (intervention). The program will last for 8 weeks, with supervised sessions twice per week. Primary outcome measures include pulmonary function (FEV₁, FVC), exercise capacity (6-minute walk test), dyspnea (mMRC and Borg scale), arterial blood gas analysis, depression level (Beck Depression Inventory), and disease-specific quality of life (St. George's Respiratory Questionnaire). WBV will be performed using a side-alternating vibration platform starting at 10 Hz and progressively increased up to 24-26 Hz over 8 weeks. All procedures will follow ATS/ERS guidelines. This study is conducted at the Chest Diseases Department of Sultan Abdulhamid Han Training and Research Hospital in Istanbul under the supervision of a multidisciplinary team. The goal is to determine whether WBV offers additional benefit in improving functional outcomes, respiratory performance, and quality of life in ILD patients undergoing PR.

Who can participate

Age range

40 Months – 80 Months

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Ages 40 to 80 years * Diagnosis of fibrotic interstitial lung disease confirmed by a multidisciplinary council (e.g., idiopathic pulmonary fibrosis, idiopathic nonspecific interstitial pneumonia, sarcoidosis, or other fibrotic patterns) * Receiving stable pharmacological treatment for at least 3 months (e.g., antifibrotic or immunosuppressive therapy) * No acute exacerbation or upper respiratory tract infection within the past 4 weeks * Able to safely participate in pulmonary rehabilitation and whole-body vibration training as determined by clinical evaluation Exclusion Criteria: * Pulmonary hypertension with systolic pulmonary artery pressure \>65 mmHg * Severe cardiovascular disease (e.g., uncontrolled hypertension, congestive heart failure, recent myocardial infarction) * Advanced renal or hepatic failure * Balance disorders preventing safe standing on a vibration platform * Severe musculoskeletal limitations (e.g., advanced arthritis, severe osteoporosis, high fall risk) * Advanced cognitive impairment or dementia * Severe psychiatric disorders (e.g., severe depression or anxiety) * Neurological diseases interfering with participation or test performance * Participation in a pulmonary rehabilitation program during the study or within the past 6 months * Pregnancy or breastfeeding * Uncontrolled metabolic diseases (e.g., advanced diabetes, uncontrolled thyroid dysfunction) * Vestibular system disorders * Active malignancy * Presence of a pacemaker o…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Six-Minute Walk Distance

Timeframe: Baseline and after 8 weeks

Trial details

NCT IDNCT07709260

SponsorIstinye University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-01

View on ClinicalTrials.gov More Interstitial Lung Diseases trials