Clinical Phenotype and Prevalence of VEXAS Syndrome in Internal Medicine

Inclusion Criteria: * Age older than 50 years. * Admission to a participating Internal Medicine department within the FADOI Friuli Venezia Giulia network. * Presence of otherwise unexplained systemic inflammation and/or hematologic abnormalities. * At least one of the following clinical or laboratory findings: * unexplained fever; * elevated C-reactive protein and/or erythrocyte sedimentation rate; * macrocytic anemia; * thrombocytopenia or other cytopenias; * systemic inflammatory manifestations without a clearly identified cause. * Availability of clinical, laboratory, and imaging data required for assessment according to the study screening pathway. * Provision of informed consent, where required by the approved study protocol and applicable regulations. Exclusion Criteria: * Systemic inflammation adequately explained by an active infection. * Systemic inflammation adequately explained by a solid malignancy. * Clinical or laboratory abnormalities with another clearly established etiology. * Insufficient clinical or laboratory information to assess eligibility according to the study screening pathway. * Inability or refusal to provide informed consent, where consent is required.