Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg
United States50 participantsStarted 2026-07-28
Plain-language summary
The objective of this study is to evaluate whether twice-daily use of Tyrvaya improves contact lens comfort in contact lens wearers.
Who can participate
Age range
18 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult male and female subjects of any race or ethnicity who are ≥18 years of age.
* Best corrected CL visual acuity of 0.3 Logarithm of the Minimum Angle of Resolution (logMAR) or better in both eyes (Snellen equivalent 20/40).
* Soft 1-day silicone hydrogel CL wearer (daily disposable only)
* Contact Lens Dry Eye Questionnaire (CLDEQ)-8 scores (CLDEQ-8 scores ≥ 12).16
* A VAS score of ≥40 for Eye Dryness and End of Day Contact Lens Discomfort;18, 19
* A corneal fluorescein staining on the original NEI scale of ≥3.
* Habitually wears soft CLs for a minimum of 5 days per week for 6 hours per day during the month prior to enrollment.20
* Willing to maintain habitual CL wear routine for the 3 months duration of the study.20
* Willing to only use Tyrvaya nasal spray prescription dry eye treatment for the 3 months duration of the study.
* Willing to not use any lipid containing artificial tear (AT) for the 3 months duration of the study.
* Willing to only use non-lipid containing preservative free artificial tear for the 3 months duration of the study if needed, but no more than 4 times per day; also must agree to record frequency of daily AT use if applicable.
* Willing to record daily time for CL application, removal, and Tyrvaya applications.
* Habitual CLs have an acceptable fit (good centration, movement, and coverage
Exclusion Criteria:
* Any history of Tyrvaya use within six months of enrollment
* Are currently an overnight CL wearer.
* Are currentl…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.