An Open-label Safety, Tolerability and Exploratory Efficacy Clinical Trial of PST-611 in Geographic Atrophy

Inclusion Criteria: * Subjects must give written informed consent, be able to make the required trial visits and follow instructions. * Female and male subjects must be 65 years of age or older. * In the study eye (SE): cRORA must be present on OCT and attributed to AMD, as evaluated by the Investigator. * Documented recent history (i.e., over 3 to 12 months prior to first PST-611 administration) of GA lesion area progression, with a yearly growth projection of ≥ 1.6 mm2, in the SE * GA lesion area prior to the first PST-611 administration must be between 1.25 mm2 and 16 mm2, as assessed by OCT, in SE. * BCVA must be \< or = 75 ETDRS letters (Snellen \< or = 20/32) in the SE. * Fixation, either central or eccentric, of both eyes, must be compatible with the performance of the ocular imaging and functional assessments included in the trial, as evaluated by the Investigator. * If both eyes are eligible, the SE will be selected by the Investigator based on the totality of the clinical evaluation. Exclusion Criteria: * Both eyes (OU): any active intraocular or periocular infection or inflammation (eg, infectious blepharitis, infectious conjunctivitis, keratitis, scleritis, endophthalmitis), or history of intraocular or periocular infection or inflammation in the 12 weeks (84 days) prior to Dose 1. * SE: any intraocular surgery (including cataract surgery) or intravitreal (IVT) or periocular corticosteroid injection in the 12 weeks (84 days) prior to Dose 1. * SE: the documente…