Research and Development of Reading Visual Aids for Low-Vision Individuals Based on Virtual Reali… (NCT07703449) | Clinical Trial Compass
CompletedNot Applicable
Research and Development of Reading Visual Aids for Low-Vision Individuals Based on Virtual Reality Technology
China58 participantsStarted 2024-06-15
Plain-language summary
Low vision substantially impairs reading ability and educational participation in adolescents. Existing assistive technologies, including optical magnifiers and electronic visual aids, are often limited by fragmented system architectures and insufficient support for multimodal cognitive processing.
This study aimed to develop and evaluate a virtual reality (VR)-based intelligent reading aid integrating image enhancement, optical character recognition (OCR), text-to-speech (TTS), and large language model (LLM)-based semantic summarization for low-vision users.
Who can participate
Age range
9 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Safety Evaluation Cohort Inclusion Criteria：
* Healthy adult volunteers aged 18-40 years
* Best-corrected binocular visual acuity of 0.8 or better
* Stereopsis of 60 arcsec or better
* Tear film break-up time of at least 10 seconds,Horizontal phoria within 15 prism diopters at both distance and near,Spherical equivalent refractive errors between plano and -6.00 D,Astigmatism not exceeding 3.00 D,Anisometropia not exceeding 2.00 D
* Intraocular pressure between 10 and 21 mmHg
* All participants provided written informed consent before enrollment
Exclusion Criteria:
* Any current or previous organic ocular disease (such as keratitis, glaucoma, or retinal detachment)
* Previous ophthalmic surgery (including refractive surgery or vitreoretinal surgery)
* Systemic or psychiatric disorders that could affect study participation
* Inability or unwillingness to complete the examination procedures
Functional Evaluation Cohort:
Inclusion Criteria:
* Aged 9-17 years
* Clinically diagnosed with visual impairment, meeting the inclusion criteria for low vision or severe visual impairment
* Sufficient basic reading ability to complete the experimental tasks
* Written informed consent obtained from all participants and their legal guardians prior to participation
Exclusion Criteria:
* Systemic or psychiatric disorders affecting participation
* Inability or unwillingness to complete the examination procedures Functional Evaluation Cohort
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Phoria
Timeframe: within 10 minutes after all reading tasks
2
Reading Completion Time
Timeframe: within 10 minutes after all reading tasks