This study evaluated the effects of NPQ Plus supplementation on skin health, antioxidant status, fatigue, and self-perceived well-being in healthy adults with skin concerns. NPQ Plus is a multi-component nutraceutical formulation containing polyphenols (Oligonol®), nicotinamide mononucleotide (NMN; RevAge®), pyrroloquinoline quinone (PQQ; PureQQ®), coenzyme Q10 (CoQ10), and a trace mineral complex (Ioniplex), which are known to possess antioxidant and cellular protective properties. This was a single-arm, open-label, prospective interventional study involving 55 participants. Subjects consumed one sachet of NPQ Plus daily for 12 weeks. Assessments were performed at baseline and at Weeks 4, 8, and 12. Skin health was evaluated using the Patient-Oriented Eczema Measure (POEM), visual analogue scale (VAS), and objective skin biophysical measurements including skin elasticity, hydration, transepidermal water loss (TEWL), pigmentation, inflammation, and sebum secretion. Antioxidant status was assessed by measuring total antioxidant capacity (TAOC), malondialdehyde (MDA), 3-nitrotyrosine (3-NT), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Fatigue symptoms and self-perceived improvements in skin health, sleep quality, and overall well-being were also evaluated.
Age range
40 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Skin Elasticity
Timeframe: Baseline, Week 4, Week 8, and Week 12
Skin Hydration
Timeframe: Baseline, Week 4, Week 8, and Week 12
Transepidermal Water Loss (TEWL)
Timeframe: Baseline, Week 4, Week 8, and Week 12
Skin Inflammation
Timeframe: Baseline, Week 4, Week 8, and Week 12
Skin Pigmentation
Timeframe: Baseline, Week 4, Week 8, and Week 12
Sebum Secretion
Timeframe: Baseline, Week 4, Week 8, and Week 12
Patient-Oriented Eczema Measure (POEM)
Timeframe: Baseline, Week 4, Week 8, and Week 12